Table 3.
Effects on Numbers of Sensory Neurons
| Sensory Population | Wild Type | BDNFneo | Reduction (%) |
|---|---|---|---|
| Trigeminal | 36,122 ± 4,267 (3) | 26,433 ± 4,140 (3) | 27a |
| Petrosal–nodose | 3,884 ± 95 (3) | 2,222 ± 135 (3) | 43b |
| Trigeminal mesencephalic nucleus | 528 ± 24 (5) | 323 ± 17 (5) | 39a |
| L4 dorsal root ganglion | 4,120 ± 357 (2) | 2,733 ± 160 (2) | 34a |
Neuron numbers (mean ± SEM) were estimated for the trigeminal (P0), the petrosal–nodose (P0), the trigeminal mesencephalic nucleus (P15), and L4 dorsal root ganglion (P15). The trigeminal mesencephalic nucleus nucleolus size (wild type, 3.4 ± 0.9 μm [n = 65]; BDNFneo, 3.5 ± 1.1 μm [n = 48]) and cell body size (wild type, 32.5 ± 0.8 μm [n = 54]; BDNFneo [−/−], 31.2 ± 0.6 μm [n = 43]) were not affected by the genotype. The sampling number is shown in parentheses. Student’s one-tailed t test determined the significance levels.
a
p < 0.05.
b
p < 0.001.