Figure 5. Genetic interactions between rad60^E380R and mutants in the HRR, or sumoylation pathways.

Representative tetrad dissections are shown when rad60^E380R was mated against: (a) rqh1Δ, (b) mus81Δ, (c) rhp51Δ, (d) nse6Δ, (e) pli1Δ, (f) nse2-SA, (g) slx8-1 and (h) ulp2Δ. For each cross a key depicts the genotypes present within each tetrad, which are denoted by various shaped white lines placed around each colony. Combining rad60^E380R with these mutants results in extreme synthetic sickness, or is a lethal event. (i) Schematic of the lethal (solid black lines) and synthetic-sick (dashed grey lines) interactions involving rad60^E380R and the indicated mutants.