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Calculated uptake of a bivalent base (bi) with the properties of chloroquine (log KOW is 4.38; pKa1 is 9.94; pKa2 is 8.10) and of a monovalent base (mono) (log KOW is 3, pKa is 8) from outside into cytosol (Cyt) and lysosomes (Lys) for varying pH in lysosomes; t = 1 h.
