Table 2.
Chemical | Valency | pKa 1 base |
pKa 2 base |
pKa acid |
log KOW |
Optimum range |
Act as |
---|---|---|---|---|---|---|---|
Amodiaquine | +3,−1 | 9.34 | 5.62 | 10.19 | 4.77 | yes | bivalent base |
Artemesinine | 0 | - | - | - | 2.27 | no | probably metabolised |
Chloroquine | +2 | 10.47 (9.94) |
6.43 (8.1) |
- | 4.69 (4.38) |
yes | bivalent base |
Cycloguanil | +2 | 9.27 | −3.55 | - | 1.19 | yes | monovalent base |
Halofantrine | +1,−1 | 9.49 | 14 | 7.92 | close | monovalent base | |
Mefloquine | +2,−1 | 10.04 | −2.30 | 12.8 | 2.87 | close | monovalent base |
Primaquine | +2 | 10.38 | 4.12 | - | 2.67 | close | bivalent base |
Pyrimethamine | +2 | 6.77 (7.2) | −0.23 | - | 2.45 | yes | monovalent base |
Quinine | +2,−1 | 9.28 (8.8) |
4.77 (4.2) |
12.8 | 3.44 | yes | bivalent base |
Quinidine | +2,−1 | (8.34) | (4.21) | 12.8 | 3.44 | yes | bivalent base |