Figure 2.

The effect of angiotensin-II in aortic strips isolated from normoglycemic (group N), normoglycemic in vivo losartan treated (group NL), diabetic (group D) and in vivo losartan treated diabetic rats (group DL). Cumulative concentration-response curves of angiotensin II (bolus) were performed on 100 nM phenylephryne (Phe) pre-contracted thoracic aortic strips stretched to 0.7 g resting tension with an endothelial-intact layer. Values are the mean ± SEM of 4 experiments. ***P < 0.001 vs. N and NL; ^§§§P < 0.001 vs. DL