Fig. 3.

Human cells in the same population that enter mitosis in the presence of microtubule poisons exhibit one of three fates. Selected frames from the same phase-contrast video recording of HeLa cells entering mitosis in 5 nM taxol. (a) This cell enters mitosis at 910 min, and then dies in mitosis at the 2190 min time point (arrow). (b) This cell enters mitosis at 1630 min, escapes mitosis (blebbing in 1890 min) to form a 4N cell (2040 min) that subsequently dies (2410 min) <10 h after exiting mitosis. (c) This cell enters mitosis at 1350 min (arrow), exits at 1560 min (arrow), and survives ≥10 h (until filming was terminated). Time, relative to addition of taxol, is shown in minutes. Bar = 10 μm.