Table 1.
Demographics and Univariate Comparisons
| Depressed subjects (n = 170) |
Control subjects (n = 83) |
Total (n = 253) |
t or χ2 | p Value | |
|---|---|---|---|---|---|
| Age | 69.4 (7.5) | 69.8 (5.6) | 69.5 (6.9) | t = 0.49 | p = 0.623 |
| Sex: female | 65.9% (112) | 73.5% (61) | 68.4% (173) | χ2 = 149 | p = 0.222 |
| Baseline MADRS | 27.0 (7.9) | -------- | 27.0 (7.9) | -------- | -------- |
| MMSE scores | 28.3 (2.0) | 29.1 (1.0) | 28.6 (1.8) | t = 3.90 | p = 0.0001 |
|
| |||||
| COMT Val158Met: | χ2 = 113 | p = 0.567 | |||
| Val/Val | 25.3% (43) | 27.7% (23) | 26.1% (66) | ||
| Val/Met | 49.4% (84) | 53.0% (44) | 50.6% (128) | ||
| Met/Met | 25.3% (43) | 19.3% (16) | 23.3% (59) | ||
|
| |||||
| MTHFR C677T: | χ2 = 103 | p = 0.598 | |||
| T/T | 11.2% (19) | 10.8% (9) | 11.1% (28) | ||
| C/T | 46.5% (79) | 53.0% (44) | 48.6% (123) | ||
| C/C | 42.4% (72) | 36.1% (30) | 40.3% (102) | ||
|
| |||||
| Left Putamen | 3.61 (0.76) | 3.65 (0.63) | 3.62 (0.72) | t = −0.34 | p = 0.731 |
| Right Putamen | 3.63 (0.78) | 3.69 (0.71) | 3.65 (0.76) | t = 0.51 | p = 0.610 |
| Cerebrum | 1156.4 (130.8) | 1163.6 (123.3) | 1158.6 (128.2) | t = 0.42 | p = 0.675 |
This table shows demographic and univariate comparisons. Continuous variables presented as mean (standard deviation). Nominal variables presented as percentage (n). Age is in years. Volume measures are in milliliters. MADRS: Montgomery-Asberg Depression Rating Scale; MMSE: Mini-Mental State Exam; COMT: Catechol-O-methyltransferase; MTHFR: methylenetetrahydrofolate reductase