The model effect of protein size on radial tortuosity () in a myofilament lattice with (thick line) and without (thin line) the myosin heads, along with the effect of protein size on longitudinal tortuosity () in a myofilament lattice with (thick dotted line) and without (thin dotted line) the myosin heads. Also shown are experimental measurements in skeletal muscle of the effect of protein size on the radial tortuoisty factor (Δ) (6,8,30,31,33) and the longitudinal tortuosity factor (○) (7,8,33). Protein size has a significant effect of tortuosity.