Table 2. Phenotypic characteristics of the BDES, BMES, and UKTS samples used for genotyping.
| Study and Covariate | Cortical | Severe Corticala | |
| UA | AFF | ||
| BDES | |||
| Total, N | 1401 | 495 | 142 |
| Average age at baseline (years) | 64 (11.0) | 61 (10.8) | 70 (8.3) |
| Gender (% of female) | 54.7 | 48.1 | 69.7 |
| % of ever smokers | 54.0 | 59.0 | 52.1 |
| % of history of heavy drinkers | 25.7 | 26.8 | 16.4 |
| % of history of diabetes | 16.0 | 12.0 | 19.0 |
| Average body mass index (kg/cm2) | 30.3 (5.8) | 30.2 (5.9) | 29.7 (5.7) |
| Average of age-related macular degeneration score | 4.8 (3.2) | 4.1 (2.7) | 5.6 (3.5) |
| Average cortical cataract score (0–100%) | 7.6 (11.9) | 0.5 (0.3) | 38.1 (12.1) |
| UKTS | |||
| Total, N | 185 | 103 | 53 |
| Average age at baseline (years) | 65 (4.5) | 64 (3.7) | 66 (4.9) |
| Gender (% of female) | 100.0 | 100.0 | 100.0 |
| % of ever smokers | 44.3 | 46.6 | 39.6 |
| Average alcohol intake | 1.9 (1.1) | 1.8 )1.2) | 2.0 (1.0) |
| Average systolic blood pressure | 132 (19) | 129 (17) | 137 (22) |
| Average cortical cataract score (0–100%) | 16 (23.2) | 0.0 (0.0) | 47.8 (18.5) |
| BMES | |||
| Total, N | 1470 | 400 | 52 |
| Average age (years) | 64 (8.2) | 70 (8.4) | 72 (7.2) |
| Gender (% of female) | 43.3 | 49.8 | 26.9 |
| % of ever smokers | 49.3 | 50.3 | 36.5 |
| % of hypertension | 54.1 | 59.2 | 63.5 |
| Average systolic blood pressure | 149 (21) | 151 (21) | 154 (20) |
| Average of age-related macular degeneration score | 8.2 (2.7) | 7.5 (2.9) | 7.0 (3.0) |
| Average cortical cataract score (0–100%) | 3.2 (7.6) | 0.1 (0.1) | 34.7 (9.4) |
Values are given as mean (standard deviation [SD]) when appropriate.
a
Severe cortical cataract represents a binary trait with a cutoff cortical score 25% for affected and with cortical scores<1% for unaffected in BDES, BMES, and UKTS. Severe cortical cataract is a subset of the cortical cataract phenotype. UA: unaffected; AFF: affected.