Table 5. P values from rank transformed traits and effect sizes from the quantitative cortical scores (β) of the risk allele at markers under the dominant model in EPHA2 for each separate study and for the joint analysis of all studies.

Trait and SNP	RAa	Individual Study Analysis (β)b				Meta-Analysis (Z-score)c
		BDES	UKTS	BMES	BMES Trend	Family Set	All
Cortical Cataract Score
rs7548209	C	0.4516	0.0524	0.0365 (0.85)	-	0.1561	0.0747
rs3754334	A	0.3935	0.0252 (2.95)	0.0734	-	0.1205	0.0180 (2.37)
Arg721Gln	A	2×10−8 (9.20)	MS	NA	-	-	-
rs3768293	G	0.0016 (1.24)	0.0439 (2.94)	0.2705	-	3×10−4 (3.65)	9×10−4 (3.34)
rs6603867	C	1×10−4 (1.58)	0.8325	0.2411	-	4×10−5 (4.13)	0.7110
rs6678616	A	7×10−5 (1.24)	0.5249	0.1520	-	1×10−4 (3.90)	1×10−4 (3.87)
Haplotype
rs7548209-rs3754334	CG	-	-	0.0024 (2.36)	-	-	-
rs7548209-rs3754334	GG	-	-	0.0202 (−0.74)	-	-	-
rs6603867-rs6678616	CA	-	-	1×10−6 (6.57)	-	-	-
Severe Cortical Cataract
rs7548209	C	4×10−6	3×10−4	0.1051	0.0027	8×10−9 (5.78)d	0.3884
rs3754334	A	0.0225	1×10−4	0.0196	0.0065	2×10−4 (3.70)d	0.1602
Arg721Gln	A	8×10−5	MS	NA	-	-	-
rs3768293	G	7×10−6	0.0040	0.0433	0.0140	9×10−8 (5.34)d	0.0037 (2.91)d
rs6603867	C	2×10−5	0.0150	0.0435	0.0265	7×10−5 (3.97)	0.0409 (2.04)
rs6678616	A	0.0215	0.0152	0.3788	0.0452	0.0014 (3.19)d	0.0271 (2.21)

Cells with a dash indicate that the analysis was not performed.

^aRA represents risk alleles (reference alleles).

^bMS and NA represent monomorphic SNPs and SNPs that were not analyzed because of small variance under the dominant model, respectively. The Cochran-Armitage (additive) trend test (BMES Trend) was also used to conduct a case-control association test of individuals age-matched for severe or no cortical cataract in the BMES. Parentheses in each individual study for cortical cataract represent effect sizes (β).

^cParentheses in meta-analysis represent Z-scores.

^dIn the meta-analyses, these SNPs for severe cortical cataract show significant P values for heterogeneity tests of effect sizes (Q test P<0.05).