Figure 7. Use of attenuated mutants identified by TMDH as live vaccines.
Growth curves for intravenous challenge of mice with SL1344 (104 CFU per mouse), 4 months after intravenous immunisation with SL1344 trxA, SL1344 atpA or SL3261 (105 CFU per mouse). Bacterial load in (A) spleens and (B) livers of immunised and age-matched un-immunised mice is shown as mean log10 CFU per organ. Error bars indicate standard error (nā=ā3ā8).
