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. 2009 May 20;96(10):3959–3976. doi: 10.1016/j.bpj.2009.02.046

Figure 6.

Figure 6

Effect of VSFP2.3 sensing capacitance on spike timing in simulations of Purkinje and layer 5 pyramidal neurons. (A) Time courses of somatic voltage transients (middle row) and VSFP2.3-induced sensing capacitance (lower row) from the onset of a constant current stimulus (shown on top, same stimulus as in Fig. 4) to the first action potential with 0 (control; gray), 200, 500, and 1000 VSDs/μm2 of VSFP2.3 (Model I). (B1) Delay of first-spike latency as function of VSFP2.3 expression density in the Purkinje neuron model. (B2) Same as B1 in the layer 5 pyramidal neuron model.