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. 2000 Sep 12;97(20):10905–10910. doi: 10.1073/pnas.200294797

Figure 5.

Figure 5

Cortical bone remodeling is rescued in TRANCE TG/KO mice. Comparison of remodeling of diaphyseal cortical bone in wild-type (wt), TRANCE KO (ko) and TRANCE TG/KO (tg/ko) mice. Periosteal surface is toward the top and endosteum toward the bottom in all panels. The TRANCE KO mice show typical osteopetrotic woven bone that has never been remodeled, with mineralized cartilage cores (c, purple) covered by bone (blue). Normal remodeled, lamellar bone (L) lacking cartilage cores is seen in the wild-type and TRANCE TG/KO diaphyses, with healthy, cuboidal osteoblasts (*) lining the endosteal bone surface, osteocytes in lacunae (arrows), and active marrow (m) in both specimens. Toluidine-blue-stained, 1-μm Epon sections, tibial diaphyses of 30-day-old animals. (Original magnification, ×1,300.)