Figure 2.

Charge transport (CT) mechanism proposed in the literature (13–15). (a) A repair enzyme (in solution) is in the 2+ state and adsorbs onto the DNA. Its iron-sulfur cluster oxidizes in the process, releasing an electron along the DNA. A repair enzyme (already adsorbed on the DNA) is in the 3+ state and accepts an incoming electron. Its iron-sulfur cluster reduces and the enzyme desorbs. (b) Guanine radicals (i.e., oxoGs) can absorb free electrons on the DNA. These radicals are annihilated upon absorbing an electron. (c) Lesions can partially reflect and absorb electrons.