Table 1.

Model parameters 1

		Comment/Reference
N		Fraction of liver mass. N = 1 for the intact liver.
M	16.8	Metabolic load.
kTNF	1.5	TNF production. Changes in TNF protein levels have not been detected after partial hepatectomy (see (39) and references within). An increase of ≈20-fold has been measured after liver injury (40). The entire priming phase ends 5–6 h after partial hepatectomy (12).
κTNF	9 × 10−1	TNF mRNA has a half-life of 45 min after stimulation with LPS (41).
VJAK	2 × 104	JAK activation.
kMJAK	1 × 104
κJAK	4 × 10−1	JAK degradation based on Siewert et al. (42).
[proSTAT3]	2	Concentration of monomeric STAT3.
VST3	7.5 × 102	STAT3 levels increase 30-fold after 2/3 partial hepatectomy (43). STAT3 degradation based on Siewert et al. (42).
kMST3	4 × 10−1
κST3	1 × 10−1
VSOCS3	2.4 × 104	SOCS3 is induced 40-fold after 2/3 partial hepatectomy (12). SOCS3 degradation based on Siewert et al. (42).
kMSOCS3	7 × 10−4
κSOCS3	4 × 10−1
kISOCS3	1.5 × 10−2	SOCS3 inhibition constant.
VIE	2.5 × 102	Typical IE gene expression levels increase 20- to 50-fold (7). c-fos mRNA has a very short half-life (<10 min) (44).
kMIE	18
κIE	5
kdeg	7	ECM degradation by TNF-activated MMPs.
κECM	33	ECM degradation.

Units: time in hours, numbers normalized to stable-state numbers, cell populations as fractions of normal liver size.