Table 1.
Characteristics of the parental strains B6 and NZO, F1 hybrids, and the F2 progeny at week 22
| B6 | NZO | F1 | F2 | |||||
|---|---|---|---|---|---|---|---|---|
| Females | ||||||||
| n | 10 | 9 | 12 | 318 | ||||
| BW, g | 24.1±1.4 | 62.7±7.6b | 42.4±6.9b | 44.2±10.6b | ||||
| BF, g | 3.6±0.7 | 39.7±8.0b | 18.0±7.1b | 22.8±10.1b | ||||
| LM, g | 18.4±0.9 | 27.2±2.3b | 25.0±2.6b | 23.8±3.2b | ||||
| BG, mM | 6.9±0.7 | 10.3±2.7a | 7.5±1.2 | 7.2±1.2 | ||||
| Males | ||||||||
| n | 6 | 7 | 7 | 331 | ||||
| BW, g | 30.5±2.9 | 71.6±7.6b | 62.1±4.8b | 58.3±7.9b | ||||
| BF, g | 3.1±1.2 | 42.0±11.6b | 26.6±4.2b | 26.4±7.2b | ||||
| LM, g | 23.6±2.0 | 29.4±4.9 | 34.8±1.5b | 32.3±3.0b | ||||
| BG, mM | 11.5±2.5 | 19.1±8.1 | 9.7±2.0 | 11.6±5.2 | ||||
Data are means ± SD. n, Number of mice; BW, body weight; BF, body fat; LM, lean mass; BG, blood glucose. Differences to B6 were analyzed by ANOVA followed by Bonferroni or Games-Howell as posthoc test
a
( P < 0.05;
b
P < 0.0001).