Fig. 3.
Genome-wide location analysis of Foxa2 in adult liver. A: experimental paradigm for the ChIP-on-Chip assay (n = 4 for each group). B: USCS Genome Browser screenshot of Foxa2 binding at the Pxr (Nr1i2) promoter. The scores for each tile indicate that the binding site is located near the middle tile (score = 9.1), close to the evolutionarily conserved region. C: confirmation of 10 randomly chosen targets found by genome-wide location analysis by QPCR. D: analysis of functional categories overrepresented in gene set bound by Foxa2.