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Regulation of Foxa2. A: an FXR/IR-1 element is present in the promoter of the mouse Foxa2 gene. FXR/IR-1 sites are also overrepresented in cis-regulatory regions of Foxa2-dependent CA-responsive targets. B: an UF1-H3β element is located in the promoter of the Foxa2 gene. UF1-H3β-like sequences are also overrepresented in cis-regulatory regions of Foxa2-dependent CA-nonresponsive targets. The curved arrow represents the autoregulatory loop of Foxa2 regulation.
