Table 1.
Demographic characteristics and correlates, overall and by silent cerebral infarct (SCI) status:
| Variables | Overall (n=2040) | SCI present (n=220) | SCI absent (n=1820) |
|---|---|---|---|
| Male (%) | 47 | 49 | 47 |
| Age (years) at 6th examination | 58 (9) | 61 (9) | 58 (9) |
| College Degree (%) | 39 | 36 | 39 |
| APOE ε4 allele (%) | 22 | 23 | 22 |
| Age (in years) at MRI | 62 (9) | 64 (9) | 62 (9) |
| Framingham Stroke Risk Profile score * | 5.4 (6.0) | 7.6 (7.8) | 5.2 (5.7) |
| Systolic Blood Pressure (mm Hg) * | 126 (18) | 132 (19) | 126 (18) |
| Current smokers (%) | 14 | 15 | 13 |
| Hypertension (%) | 37 | 50 | 35 |
| Diabetes (%) | 8.7 | 12.7 | 8.2 |
| Left Ventricular Hypertrophy (%) | 0.3 | 0.5 | 0.3 |
| Cardio Vascular Disease (%) | 7.7 | 11.8 | 7.1 |
| Atrial fibrillation (%) | 2.2 | 5.0 | 1.9 |
| Plasma tHcy‡ (mmol/l)† | 8.9 (78.7) | 9.9 (44.3) | 8.8 (78.7) |
| tHcy – top quartile‡ | 25 | 35 | 24 |
| Total Cholesterol | 205 (37) | 209 (35) | 204 (37) |
| High Density Lipoprotein Cholesterol* | 51 (16) | 51 (16) | 52 (16) |
| Carotid Stenosis 25% + (%) | 15 | 24 | 14 |
| CCIMT†§ | 0.69 (1.41) | 0.72 (1.01) | 0.69 (1.41) |
| ICAIMT† ∥ | 0.79 (6.71) | 0.90 (2.97) | 0.78 (6.71) |
| LVM† # | 157 (307) | 159 (220) | 157 (307) |
| LVM_HGT† ** | 2.40 (4.29) | 2.45 (3.25) | 2.40 (4.29) |
*
mean (sd)
†
median (range)
‡
plasma total homocysteine
§
common carotid artery intima media thickness
∥
internal carotid artery intima media thickness
#
left ventricular mass
**
left ventricular mass adjusted for height