TABLE 2.
Qualitative summary of predictions of 1:1 phase-locking using first- and second-order phase response curves (F1 and F2)
| Model Neuron | Biological Neuron | gmodel>bio, nS |
gbio>model, nS |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 10 | 20 | 30 | 60 | 80 | 100 | 300 | 10,000 | |||
| 1 | 3 | 30 | −/− | −/− | −/a | a/a, DB | |||||
| 1 | 3 | 100 | −/− | −/− | |||||||
| 1 | 4 | 10 | −/− | −/− | c/− | a/a | |||||
| 1 | 4 | 30 | −/− | −/− | c/− | a/a | |||||
| 1 | 5 | 10 | c/− | −/− | −/− | −/− | −/− | ||||
| 1 | 5 | 30 | c/− | −/− | −/− | c/− | |||||
| 2 | 1 | 20 | −/− | c/− | a/− | a/− | a/a | a/a | a/a | ||
| 2 | 1 | 60 | c/− | −/− | −/− | −/− | |||||
| 2 | 2 | 30 | a/a | a/−, N | a/a | ||||||
| 2 | 2 | 60 | −/a, N | a/a | a/a, DB | ||||||
| 2 | 2 | 150 | a/a | ||||||||
| 2 | 5 | 10 | c/− | c/− | c/− | c/− | c/− | −/− | |||
| 2 | 5 | 30 | c/− | c/− | c/a | a/a | |||||
| 2 | 5 | 100 | c/a, N | −/− | −/a, RE | −/a, RE | |||||
| 3 | 1 | 20 | a/a | a/a | a/a | a/a | |||||
| 3 | 2 | 30 | a/a | ||||||||
| 3 | 4 | 10 | a/a | a/a | a/a | ||||||
| 3 | 4 | 30 | a/a | a/a | a/a | a/a | |||||
| 3 | 4 | 100 | −/− | −/a, RE, N | −/a, RE | −/a, RE, N | |||||
| 3 | 5 | 10 | c/− | c/a, N | c/a, N | c/a, N | |||||
| 4 | 5 | 30 | −/− | −/a, RE, N | a/a | ||||||
| 4 | 5 | 10 | −/a, RE, N | −/a, RE | a/a | ||||||
| 4 | 5 | 30 | a/−, N | −/− | −/a, RE | ||||||
| 4 | 5 | 100 | a/a | −/a, RE, N | −/− | ||||||
Each cell represents one hybrid network. Each network is defined by one model neuron (column 1), one biological neuron (column 2), and the maximal conductances of their artificial synapses (columns 3 and 4–12). Classifications of observed and predicted network activity are coded and displayed as “observed”/“predicted,” where a network may be observed to exhibit one of three types of behavior: 1:1 phase-locking (“a”), no phase-locking (“−”), or higher modes of phase-locking, which we call complex modes (“c”). Networks of interest are marked by a symbol following a comma; they are runaway excitation (RE), noise-induced mode transitions (N), and depolarization block (DB). These are discussed in the text. Individual networks are also color coded according to the accuracy of our method in predicting the observation of phase-locking. Cells are colored green to indicate that our method was successful, red to indicate failure, and yellow to indicate failure under special circumstances (see Special cases for further explanation).