Effect of thalamic disinhibition on VPM cell responses to corticothalamic stimulation. A: population PSTHs show responses evoked by the 10th stimulus in a 10-pulse train delivered at 0.1, 10, and 40 Hz during control (black) and during thalamic disinhibition (BC; red). The responses shown in the left and middle panels are overlaid in the right panel. B: corticothalamic responses, measured during a 1- to 20-ms window poststimulus, evoked in VPM cells during control (black symbols) and during thalamic disinhibition (BC; gray symbols). The x axis shows the responses evoked by each of the 10 stimuli in the 10-Hz train. Each block of 10 stimuli correspond (left to right) to corticothalamic stimulation delivered to the thalamic radiation at 2, 5, 10, 20, and 40 Hz. Inset: asterisk makrs the responses that showed a significant effect of disinhibition as determined with a pair-wise comparison. The gray color fill highlights that the effect of disinhibition was to significantly suppress, rather than enhance, the evoked response.