Table 2.
Comparison of clinical and hormonal parameters in patients who achieved target height versus those who did not
| Achieved target height | Did not achieve target height | P value | Controls | |
|---|---|---|---|---|
| Children—number | 14 | 6 | ||
| Mean (SD) age (years) | 11.46 (3.52) | 12.5 (3.08) | Ns | |
| M:F | 10:4 | 1:5 | 12:2 | |
| Age at first presentation (years) | 5.71 (2.97) | 4.17 (2.31) | 0.2 | |
| Duration of disease (years) | 5.25 (2.80) | 8.33 (3.47) | 0.04 | |
| Hemoglobin (g/dl) | 8.98 (2.47) | 9.17 (1.84) | Ns | |
| Total WBC count (/cmm) | 6371.43 (5047.99) | 3950.00 (2364.53) | Ns | |
| Platelets (/cmm) | 166571.43 (81646.25) | 66333.33 (20848.66) | 0.009 | |
| Albumin (g/dl) | 3.74 (0.59) | 3.51 (0.49) | Ns | |
| Spleen size at Ultrasonography (cm) | 14.68 (2.96) | 15.97 (2.85) | Ns | |
| IGF-1 Log normal | −1.1719 | −0.799 | Ns | |
| IGFBP3 Log normal | −0.818 | −0.486 | Ns | |
| Adults—number | 25 | 7 | 14 | |
| Mean (SD) age, (years) | 25.34 (6.60) | 27.14 (8.91) | Ns | 22.43 (5.85) |
| M:F | 22:3 | 4:3 | 12:2 | |
| Mean age at presentation (years) | 9.17 (3.17) | 13.92 (4.25) | 0.032 | – |
| Height (m) | 1.62 (0.07) | 1.51 (0.15) | 0.007 | 156.1 (5.35)* |
| Weight (kg) | 48.30 (7.17) | 39.76 (9.25) | 0.014 | |
| BMI (kg/m2) | 18.38 (2.33) | 17.65 (3.98) | Ns | |
| Mean (SD) Duration of disease (years) | 15.86 (6.28) | 13.07 (5.93) | 0.5 | – |
| Hemoglobin (g/dl) | 10.25 (2.65) | 8.43 (2.85) | Ns | |
| Total WBC count (/cmm) | 4912.00 (2785.13) | 6142.86 (4078.34) | Ns | |
| Platelets (/cmm) | 142960.00 (70854.00) | 185857.14 (76141.16) | Ns | |
| Albumin (g/dl) | 3.54 (0.56) | 3.66 (0.42) | Ns | |
| Spleen size at Ultrasonography (cm) | 18.34 (3.970) | 15.96 (5.54) | Ns | |
| IGF-1 Log normal | −0.668 | −0.762 | Ns | |
| IGFBP3 Log normal | −0.685 | −0.631 | Ns |
IGF1: Insulin-like Growth Factor-1
IGFBP3: Insulin-like Growth Factor Binding Protein-3
* Mid-parental height