Table 3.

Common practices for stage-specific and survival-related stage work-up

	Pathologic stage
	0	I		II			III			IV
		A	B	A	B	C	A	B	C
Ultrasound nodal basin			E	E	E	E	E	E	E
Chest X-ray			E	E	E	E	W	W	W	W
Ultrasound abdomen			E	E	E	E	E	E	E	E
LDH and S100B			E	E	E	E	E	E	E	W
CT chest, abdomen, pelvis						E	E	W	W	W
Brain MRI								W	W	W
PET or PET/CT								E	E	R

E, used in various European countries [2, 3] but unproven utility; W, commonly used worldwide but without proven impact on overall survival in the total melanoma population; R, most useful in patients with potentially resectable disease.