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Roles for Sis1 in [RNQ+] prion assembly. The [RNQ+] prion acts as a template to alter the conformation of native Rnq1 into an assembly competent monomer. Sis1 promotes the appropriate packaging of templated Rnq1 monomers into higher-ordered [RNQ+] prions via a fragmentation and elongation model. Inefficiencies in this assembly process by Rnq1 overexpression or Sis1 depletion enable templated monomers to accumulate as soluble, proteotoxic species.
