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. 2009 Apr-Jun;3(2):99–109. doi: 10.4161/pri.3.2.9059

Figure 2.

Figure 2

Spongiosis and astrocytosis in mice treated with cuprizone, infected with RML or controls. (A, D, G, J and M) Hematoxylin and eosin staining shows spongiosis in the white matter of the cerebellum after eight weeks of cuprizone treatment and after 158 and 198 days of RML infection. (B, E, H, K and N) Anti-GFAP immunohistochemistry shows star-shaped astrocytosis in the frontal cortex after cuprizone treatment and after 158 and 198 days of RML infection. (C, F, I, L and O) PrPTSE staining in the medulla. Red, positive staining can be seen at 158 and 198 dpi and is not observed after cuprizone treatment. Scale bars: (A, D, G, J, M, F, L and O) = 50 µm; (B, E, H, K, N, C and I) = 100 µm.