Table 1.
Previously unidentified, differentially regulated gene expression changes in RML-infected brain tissue
| Probe set ID | Gene symbol | Gene title | 108 dpi | 158 dpi | 198 dpi |
| Immune Response | |||||
| 1431591_s_at | Isg15 | ISG15 ubiquitin-like modifier | 1.2 | 2.3 | 2.1 |
| 1418392_a_at | Gbp3 | guanylate binding protein 3 | 1.2 | 1.8 | 1.7 |
| 1426397_at | Tgfbr2 | transforming growth factor, beta receptor II | 1.1 | 1.2 | 1.7 |
| 1424617_at | Ifi35 | interferon-induced protein 35 | 1.1 | 1.6 | 1.6 |
| 1451318_a_at | Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 1.4 | 1.4 | 1.6 |
| 1425156_at | Gbp6 | guanylate binding protein 6 | 1.1 | 1.7 | 1.5 |
| 1418641_at | Lcp2 | lymphocyte cytosolic protein 2 | 1.0 | 1.6 | 1.4 |
| Intracellular Signaling Cascade | |||||
| 1460287_at | Timp2 | tissue inhibitor of metalloproteinase 2 | 1.3 | 1.6 | 2.6 |
| 1460188_at | Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 1.6 | 1.9 | 2.4 |
| 1455132_at | A430107D22Rik | RIKEN cDNA A430107D22 gene | 1.5 | 1.5 | 1.4 |
| 1452398_at | Plce1 | phospholipase C, epsilon 1 | 1.1 | 1.3 | 1.6 |
| 1438936_s_at | Ang | angiogenin, ribonuclease, RNase A family, 5 | 1.0 | 1.4 | 1.9 |
| 1428479_at | Nfatc1 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | 1.6 | 1.3 | 1.4 |
| 1416675_s_at | Plcd1 | phospholipase C, delta 1 | 1.6 | 1.2 | 1.2 |
| Protein Modification Process | |||||
| 1418191_at | Usp18 | ubiquitin specific peptidase 18 | 1.5 | 3.6 | 3.9 |
| 1451584_at | Havcr2 | hepatitis A virus cellular receptor 2 | 1.3 | 1.8 | 2.1 |
| 1416340_a_at | Man2b1 | mannosidase 2, alpha B1 | 1.5 | 1.4 | 1.7 |
| 1449342_at | Ptplb | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b | −1.1 | 1.4 | 1.5 |
| 1433768_at | Palld | palladin, cytoskeletal associated protein | 1.3 | 1.1 | 1.5 |
| Response to Stimulus | |||||
| 1423547_at | Lyz2 | lysozyme 2 | 1.8 | 3.4 | 5.5 |
| 1421009_at | Rsad2 | radical S-adenosyl methionine domain containing 2 | 1.3 | 2.1 | 2.2 |
| 1424254_at | Ifitm1 | interferon induced transmembrane protein 1 | −1.1 | 1.7 | 1.1 |
| Ubiquitin Cycle | |||||
| 1433664_at | Ube2q2 | ubiquitin-conjugating enzyme E2Q (putative) 2 | −1.3 | −1.3 | −1.5 |
| 1419562_at | Birc6 | baculoviral IAP repeat-containing 6 | −1.8 | −1.2 | −1.3 |
| Cellular Developmental Process | |||||
| 1437947_x_at | Vdac1 | voltage-dependent anion channel 1 | −1.2 | −1.7 | −1.3 |
| 1453134_at | Pik3ca | phosphatidylinositol 3-kinase, catalytic, alpha polypeptide | −1.7 | −1.4 | −1.3 |
| 1449044_at | Eef1e1 | eukaryotic translation elongation factor 1 epsilon 1 | −1.7 | 1.0 | −1.1 |
| Other | |||||
| 1448891_at | Fcrls | Fc receptor-like S, scavenger receptor | 2.2 | 2.0 | 2.8 |
| 1421457_a_at | Samsn1 | SAM domain, SH3 domain and nuclear localization signals, 1 | 1.3 | 1.9 | 2.3 |
| 1451655_at | Slfn8 | schlafen 8 | 1.1 | 1.8 | 2.3 |
| 1418825_at | Irgm | immunity-related GTPase family, M | 1.2 | 2.0 | 2.3 |
| 1420591_at | Gpr84 | G protein-coupled receptor 84 | 1.4 | 1.7 | 2.2 |
| 1424754_at | Ms4a7 | membrane-spanning 4-domains, subfamily A, member 7 | −1.0 | 1.3 | 2.1 |
| 1443698_at | Xaf1 | XIAP associated factor 1 | 1.1 | 1.8 | 2.1 |
| 1436346_at | Cd109 | CD109 antigen | 1.1 | −1.1 | 2.1 |
| 1449227_at | Ch25h | cholesterol 25-hydroxylase | 1.1 | 1.6 | 2.0 |
| 1451564_at | Parp14 | poly (ADP-ribose) polymerase family, member 14 | 1.4 | 1.9 | 2.0 |
| 1421408_at | Igsf6 | immunoglobulin superfamily, member 6 | 1.2 | 1.3 | 2.0 |
| 1454757_s_at | D12Ertd647e | DNA segment, Chr 12, ERATO Doi 647, expressed | 1.2 | 1.7 | 1.9 |
| 1451537_at | Chi3l1 | chitinase 3-like 1 | 1.1 | 1.7 | 1.8 |
| 1419879_s_at | Trim25 | tripartite motif-containing 25 | 1.2 | 1.3 | 1.8 |
| 1456133_x_at | Itgb5 | integrin beta 5 | 1.5 | 1.3 | 1.8 |
| 1421374_a_at | Fxyd1 | FXYD domain-containing ion transport regulator 1 | −1.6 | 1.4 | 1.8 |
| 1448561_at | Ncf2 | neutrophil cytosolic factor 2 | 1.4 | 1.6 | 1.8 |
| 1451132_at | Pbxip1 | pre-B-cell leukemia transcription factor interacting protein 1 | 1.3 | 1.3 | 1.8 |
| 1426454_at | Arhgdib | Rho, GDP dissociation inhibitor (GDI) beta | 1.1 | 1.7 | 1.7 |
| 1449591_at | Casp4 | caspase 4, apoptosis-related cysteine peptidase | 1.0 | 1.5 | 1.7 |
| 1434945_at | Lpcat2 | lysophosphatidylcholine acyltransferase 2 | 1.2 | 1.3 | 1.7 |
| 1450234_at | Ms4a6c | membrane-spanning 4-domains, subfamily A, member 6C | 1.3 | 1.7 | 1.7 |
| 1460351_at | S100a11 | S100 calcium binding protein A11 (calgizzarin) | −1.6 | 1.4 | 1.7 |
| 1422571_at | Thbs2 | thrombospondin 2 | 1.2 | 1.3 | 1.6 |
| 1429525_s_at | Myo1f | myosin IF | 1.2 | 1.5 | 1.6 |
| 1418099_at | Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 1.2 | 1.4 | 1.6 |
| 1458019_at | Mus musculus Transcribed locus | 1.0 | 1.4 | 1.6 | |
| 1424829_at | A830007P12Rik | RIKEN cDNA A830007P12 gene | 1.3 | 1.2 | 1.5 |
| 1454748_at | Naprt1 | nicotinate phosphoribosyltransferase domain containing 1 | 1.6 | 1.3 | 1.5 |
| 1451139_at | Slc39a4 | solute carrier family 39 (zinc transporter), member 4 | 1.3 | 1.1 | 1.5 |
| 1437886_at | Klhl6 | kelch-like 6 (Drosophila) | 1.2 | 1.3 | 1.5 |
| 1420624_a_at | Vamp8 | vesicle-associated membrane protein 8 | −1.5 | 1.2 | 1.3 |
| 1421221_at | Bco2 | beta-carotene oxygenase 2 | 1.3 | 1.5 | 1.3 |
| 1449960_at | Nptx2 | neuronal pentraxin 2 | −1.2 | 1.5 | 1.3 |
| 1418451_at | Gng2 | guanine nucleotide binding protein (G protein), gamma 2 | −1.5 | 1.1 | 1.2 |
| 1424058_at | Prrc1 | proline-rich coiled-coil 1 | 1.5 | 1.1 | 1.2 |
| 1427903_at | Phpt1 | phosphohistidine phosphatase 1 | −1.7 | 1.1 | 1.1 |
| 1419812_s_at | Ccdc56 | coiled-coil domain containing 56 | −1.6 | 1.1 | 1.0 |
| 1426187_a_at | Hax1 | HCLS1 associated X-1 | −1.6 | 1.1 | 1.0 |
| 1417653_at | Pvalb | parvalbumin | −2.6 | 1.0 | 1.0 |
| 1435522_a_at | 2310016E02Rik | RIKEN cDNA 2310016E02 gene | −2.0 | 1.1 | 1.0 |
| 1428464_at | Ndufa3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 | −2.1 | 1.1 | 1.0 |
| 1416979_at | Pomp | proteasome maturation protein | −1.6 | 1.1 | 1.0 |
| 1424122_s_at | Commd1 | COMM domain containing 1 | −1.7 | 1.2 | −1.0 |
| 1416277_a_at | Rplp1 | ribosomal protein, large, P1 | −1.6 | 1.1 | −1.0 |
| 1450818_a_at | Ndufa7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a) | −1.5 | 1.1 | −1.0 |
| 1452790_x_at | Ndufa3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 | −2.0 | 1.0 | −1.0 |
| 1427102_at | Slfn4 | schlafen 4 | 1.1 | 1.8 | −1.0 |
| 1434391_at | Hnrnpu | Heterogeneous nuclear ribonucleoprotein U | −1.7 | 1.1 | −1.0 |
| 1418083_at | 0610009B22Rik | RIKEN cDNA 0610009B22 gene | −1.5 | −1.0 | −1.1 |
| 1442887_at | AI853363 | expressed sequence AI853363 | −1.7 | −1.0 | −1.2 |
| 1422884_at | Snrpd3 | small nuclear ribonucleoprotein D3 | −1.7 | 1.5 | −1.4 |
| 1428570_at | Ccnc | cyclin C | −1.5 | −1.4 | −1.4 |
| 1450770_at | 3632451O06Rik | RIKEN cDNA 3632451O06 gene | −1.3 | −1.4 | −1.5 |
| 1417121_at | Gabra6 | gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6 | −1.1 | −1.3 | −1.6 |
| 1433452_at | B630019K06Rik | RIKEN cDNA B630019K06 gene | −1.1 | −1.5 | −1.6 |
Transcripts were subjected to the Gene Ontology classification system for discovery of biological processes affected by prion disease. Fold change vs. control at three time points are shown here.