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. Author manuscript; available in PMC: 2009 Sep 17.
Published in final edited form as: J Am Chem Soc. 2008 Aug 19;130(37):12244–12245. doi: 10.1021/ja804541s

Figure 2.

Figure 2

Local nucleotide structure in RNA analyzed by SHAPE and S2. (A) Secondary structures for the TAR, U1A target, and T-SL4 RNAs. Nucleotides with SHAPE reactivities greater than 0.5 for TAR and U1A, or greater than 0.6 for T-SL4 are red. Positions for which S2 was not obtained are shown as red or black spheres. (B). Histograms of SHAPE reactivities as a function of nucleotide position (columns) compared to 1-S2 measurements (blue spheres).