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. Author manuscript; available in PMC: 2009 Jul 19.
Published in final edited form as: Bioconjug Chem. 2008 May 24;19(6):1164–1169. doi: 10.1021/bc700442g

Figure 4.

Figure 4

Figure 4

SEM images of particles formulated with PK3. (A) SEM image of empty particles formulated via double emulsion. (B) SEM images of imatinib-loaded PK3 microparticles formulated via double emulsion. (C) Size Distribution of imatinib-loaded PK3 microparticles as determined by dynamic light scattering (DLS).

PK3 microparticles improve the efficacy of imatinib in treating acute liver failure in mice. Mice were injected intravenously with either imatinib or imatinib in PK3 microparticles, acute liver failure was then induced by intraperitoneal injection of Con A (15 mg/kg). 8 hours later, ALT levels in the blood were analyzed. * indicates statistical significance (Student’s t test, P < 0.05, n = 4 to 8).