Table 2.
Hydrolysis half-lives of polyketal copolymers at pH 4.5 and pH 7.4, at 37 °C.
| PK ID | Polymer composition | Half life at pH 4.5 |
Estimated half life at pH 7.4 |
log P of diol B* |
|||
|---|---|---|---|---|---|---|---|
| Diol A | Percent diol A |
Diol B | Percent diol B |
||||
| PK4 | 1,4-cyclohexane dimethanol |
96.75% | 1,4-butanediol | 3.25% | 1.0 day | 54 days | −0.83 |
| PK3 | 86.70% | 1,5-pentanediol | 13.30% | 1.8 days | 39 days | 0.27 | |
| PK5 | 85.32% | 1,6-hexanediol | 14.68% | 4.4 days | 53 days | 0.76 | |
| PK6 | 87.31% | 1,8-octanediol | 12.69% | 18.6 days | 360 days | 1.75 | |
*
log P is the logarithm of the water/octanol partition coefficient; the log P data were obtained from the Syracuse Research Corporation’s PhysProp Database.