Table 3.
Association between LINE-1 methylation and dietary intake of B-vitamins and multivitamin use
| Counts‡ | Overall | Left side | Right side | p-value¥ | ||||
|---|---|---|---|---|---|---|---|---|
| NT/NL/NR | Mean (95% CI) | p-value§ | Mean (95% CI) | p-value§ | Mean (95% CI) | p-value§ | ||
| Dietary folate (mcg/day) | ||||||||
| Q1 (78.08-205.86) | 94/94/93 | 64.66 (64.09-65.23) | 0.02 | 64.85 (64.18-65.51) | 0.32 | 64.47 (63.83-65.11) | <0.01 | 0.10 |
| Q2 (206.87-277.3) | 94/94/94 | 64.82 (64.69-65.32) | 65.47 (64.79-66.16) | 64.16 (63.59-64.73) | ||||
| Q3 (277.31-373.65) | 94/94/93 | 64.05 (63.55-64.56) | 64.57 (63.95-65.19) | 63.53 (62.94-64.12) | ||||
| Q4 (376.17-1285.59) | 93/91/92 | 63.92 (63.36-64.48) | 64.63 (63.96-65.31) | 63.22 (62.61-63.82) | ||||
| Dietary B2 (mg/day) | ||||||||
| Q1 (0.39-1.18) | 98/98/97 | 64.73 (64.18-65.28) | 0.57 | 65.22 (64.52-65.92) | 0.75 | 64.24 (63.67-64.82) | 0.16 | 0.12 |
| Q2 (1.19-1.57) | 92/92/92 | 64.17 (63.64-64.70) | 64.36 (63.73-65.00) | 63.97 (63.33-64.61) | ||||
| Q3 (1.60-2.20) | 92/92/92 | 64.03 (63.56-64.48) | 64.66 (64.03-65.30) | 63.39 (62.89-63.89) | ||||
| Q4 (2.21-6.56) | 93/91/91 | 64.53 (63.93-65.13) | 65.29 (64.62-65.96) | 63.77 (63.09-64.45) | ||||
| Dietary B6 (mg/day) | ||||||||
| Q1 (0.33-1.08) | 99/99/99 | 64.72 (64.17-65.28) | 0.17 | 64.99 (64.31-65.66) | 0.77 | 64.46 (63.87-65.04) | 0.04 | 0.32 |
| Q2 (1.09-1.54) | 89/89/88 | 64.23 (63.68-64.78) | 64.76 (64.13-65.39) | 63.70 (63.05-64.35) | ||||
| Q3 (1.55-2.00) | 95/95/94 | 64.38 (63.90-64.86) | 65.02 (64.32-65.71) | 63.76 (63.25-64.27) | ||||
| Q4 (2.01-6.20) | 92/90/91 | 64.11 (63.56-64.65) | 64.76 (64.12-65.39) | 63.45 (62.80-64.11) | ||||
| Multivitamin use | ||||||||
| No | 256/255/253 | 64.22 (63.90-64.53) | 0.12 | 64.72 (64.31-65.13) | 0.18 | 63.71 (63.35-64.06) | 0.10 | 0.97 |
| Yes | 130/130/130 | 64.67 (64.20-65.13) | 65.19 (64.65-65.72) | 64.15 (63.61-64.70) | ||||
‡
NT = total individuals; NL = total individuals with samples on the left side; NR = total individuals with samples on the right side;
§
p-value for trend;
¥
p-value for interaction testing differences between right and left side of the colorectum.
¶
Quartiles of the residuals of the regression of the logarithm of the nutrient on the logarithm of kilocalories. Means are adjusted for energy intake using the logarithm of caloric intake. Quartiles ranges are based in a 2000 calories/day diet.