Table 2.

Positive predictive values of FOBT alone or in combination with stool K-ras results, for the detection of malignancies, adenomas, any tumors or benign non-neoplastic findings in the colon

Findings in colon	Any FOBT+	FOBT+ >4 fields	Any K-ras+ In FOBT+	FOBT>4 + K-ras+
N	130	41	32	10
Adenocarcinoma	23	13	8	6
PPV	17.7% (2.1–33.3)	31.7% (12.7–50.7)	25.0% (7.3–42.7)	60.0% (40.0–80.0)
Adenoma	25	9	8	2
PPV	19.2% (3.8–34.7)	22.0% (5.7–38.2)	25.0% (8.0–42.0)	20.0% (4.3–35.7)
All Neoplasms*	62	25	17	8
PPV	47.7% (35.3–60.1)	61.0% (48.8–73.1)	53.1% (40.7–65.5)	80.0% (70.0–90.0)
No-neoplastic GI disease**	46	13	9	1
PPV	35.4% (21.6–49.2)	31.7% (18.3–45.2)	28.1% (15.1–41.1)	10.0% (1.3–18.7)
Normal colonoscopy***	22	3	6	1
PPV	16.9%	7.3%	18.8%	10.0%

^*Includes adenocarcinomas, adenomas and polyps NOS

^**Includes diverticulosis, hemorrhoids, IBD.

^***does not preclude upper GI findings