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. 2009 Jul 28;4(7):e6389. doi: 10.1371/journal.pone.0006389

Figure 6. HR defects are associated with decreased frequencies of predicted dicentric GCRs.

Figure 6

A total of 366 events were analyzed including 225 predicted monocentric GCRs (de novo telomere addition GCRs where excluded from this analysis) and 141 predicted dicentric GCRs; these GCRs are described in [30]. The percentage of predicted monocentric GCRs and dicentric GCRs were determined for each indicated group of strains. Telomerase deficient includes all strains that contain tlc1 or est2 mutations. CHEK includes strains that contain chk1, dun1, mec1, mec3, pds1, rad9, rad53 and/or tel1 mutations, REC includes strains that contain rad51, rad52, rad54, rad55, rad59 and/or rdh54 mutations and NHEJ includes strains that contain lig4, ku70, ku80 or mre11 mutations. Strains containing other mutations that might affect these different pathways were not included in this analysis. Numbers above the histogram indicate the actual number of GCRs in each group.