Dichotomized combination variables of EPHB6/TrkA,
EFNB2/TrkA, and EFNB3/TrkA strongly
predict outcome of NB. Dichotomized variables were generated based on
TrkA expression and EPHB6,
EFNB2, or EFNB3 expression. One category
included NB expressing low levels of both TrkA and
EPHB6, EFNB2 or EPNB3,
(group 1 in Fig. 2), whereas the other included NB expressing high
levels of either one or both (combination of groups 2, 3, and 4 in Fig.
2). Survival probabilities of each two groups of NB defined by the
dichotomized combination variables, EPHB6/TrkA
(A), EFNB2/TrkA (B), and
EFNB3/TrkA (C), were estimated by the
method of Kaplan-Meier. The log-rank test was used to compare survival
probabilities of the groups. CI, Confidence interval.