Skip to main content
. Author manuscript; available in PMC: 2009 Jul 20.
Published in final edited form as: Nat Biotechnol. 2009 Feb 22;27(3):264–274. doi: 10.1038/nbt.1526

Figure 4.

Figure 4

Using SB-induced tumorigenesis to derive clonal relationships between primary and metastatic derivatives. (a) Heat-map showing the clonal relationship between lung metastases and HCC samples. Heat-map was generated by mapping insertion sites from 32 lung metastases nodules and 3 HCC nodules taken from the same experimental mouse (ATRP M232). Importantly, 3 additional insertion mutations were common in most of the metastases, indicating potential genes involved with the metastatic process. Red, insertion detected at the indicated locus; Black, no insertion detected at the indicated locus. (b) Phylogenic tree generated from the insertion sites of the lung metastases and HCCs.