Table 1. Similarities in Characteristics and Immunomodulatory Activities of the T Cell Receptor Core Peptide and HIV-1 gp41 Fusion Peptide.

Characteristics/Activation Model	CP [17], [24]–[26]	FP [29]
Colocalization with TCR	+	+
Coprecipitation with TCR	+	+
Immunosuppressive activity in vivo	+	+
Inhibition of in vitro activation:
Antigen	+	+
Anti-TCRβ antibody	—	ND
Anti-CD3 antibody	—	—
PMA/ionomycin	—	—

TCR, T cell receptor; CP, core peptide; FP, fusion peptide; ND, not determined; PMA, phorbol 12-myristate 13-acetate.