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SPARC during VLCD 16-week 450 kcal/day in subjects with (METS+) and without (METS−) the metabolic syndrome. Data from SPARC adipose tissue expression of subjects of both groups were compared with their baseline levels (top) and the within-patient variation with the previous time point. R, refeeding; W, week. **P < 0.01, ***P < 0.001, n = 24.
