TABLE 4.
SPARC and metabolic parameters and cytokines
| SCAT | VAT | |
|---|---|---|
| Waist circumference (cm) | R = 0.37, P < 0.01 | R = 0.23, P < 0.05 |
| Fat mass (kg) | R = 0.4, P < 0.01 | R = 0.3, P < 0.05 |
| Total cholesterol (mmol/l) | R = 0.008, P = NS | R = 0.23, P < 0.05 |
| Fasting insulin (μIU/ml) | R = 0.31, P < 0.05 | R = 0.34, P < 0.05 |
| Fasting glucose (mmol/l) | R = 0.23, P = NS | R = 0.3, P < 0.05 |
| HOMA-IR | R = 0.32, P < 0.05 | R = 0.36, P < 0.05 |
| Circulating leptin (ng/ml) | R = 0.38, P < 0.05 | R = 0.17, P = NS |
| Circulating adiponectin (ng/ml) | R = −0.22, P = NS | R = −0.37, P < 0.05 |
| Circulating IL-6 (ng/ml) | R = 0.26, P = NS | R = 0.01, P = NS |
| Circulating TNF-α (ng/ml) | R = 0.16, P = NS | R = 0.03, P = NS |
| hsCRP (mmol/l) | R = 0.44, P < 0.01 | R = 0.31, P < 0.05 |
| Adipose tissue leptin | R = 0.68, P < 0.001 | R = 0.55, P < 0.001 |
| Adipose tissue adiponectin | R = −0.3, P < 0.05 | R < 0.01, P = NS |
| Adipose tissue IL-6 | R = −0.3, P < 0.05 | R = −0.014, P = NS |
| Adipose tissue MMIF | R = −0.3, P < 0.05 | R = 0.3, P < 0.05 |
| Adipose tissue TNF-α | R = 0.07, P = NS | R = 0.03, P = NS |
| Adipose tissue MIP-1 | R = 0.03, P = NS | R = −0.47, P = NS |
| Adipose tissue MCP-1 | R = 0.055, P = NS | R = −0.14, P = NS |
| Adipose tissue RANTES | R = 0.077, P = NS | R = 0.017, P = NS |
SPARC depot-specific expression in relation to metabolic parameters, circulating cytokine levels, and adipose tissue expression of adipokine/cytokine corresponding to the depot studied. RANTES, regulated upon activation normal T-cell expressed and secreted. n = 56, significant correlations are shown in bold.