TABLE 1.

Influence of SK4-KO on glucose tolerance and insulin sensitivity

	Plasma glucose (mmol/l)
	12 weeks		24 weeks
	WT	SK4-KO	WT	SK4-KO
Time after injection of:
Glucose
0 min (fasted)	5.8 ± 0.6	6.6 ± 0.5	5.6 ± 0.4	6.4 ± 0.3
15 min	15.7 ± 1.6	10.0 ± 0.6†	21.9 ± 0.9	18.6 ± 0.7*
30 min	18.9 ± 1.7	10.7 ± 0.6†	27.1 ± 1.0	22.7 ± 0.5†
60 min	18.0 ± 1.8	8.6 ± 1.0†	22.1 ± 1.9	15.4 ± 0.9†
120 min	9.5 ± 1.2	6.2 ± 0.5*	10.2 ± 1.0	6.4 ± 0.1†
Insulin
0 min (fed)	11.1 ± 1.1	10.4 ± 0.8	11.2 ± 0.6	10.6 ± 0.5
15 min	7.0 ± 0.4	7.2 ± 1.0	7.3 ± 0.4	6.8 ± 0.3
30 min	5.4 ± 0.3	5.3 ± 0.4	6.0 ± 0.2	5.7 ± 0.3
60 min	4.2 ± 0.2	4.7 ± 0.5	5.7 ± 0.5	5.7 ± 0.8

Summary of glucose and insulin tolerance tests obtained from 12- and 24-week-old SK4-KO and WT mice. Plasma glucose concentration was monitored for 2 and 1 h after intraperitoneal injection of 2 g/kg body wt glucose or 0.7 IU/kg body wt insulin, respectively. (Five to six SK4-KO and WT littermates were tested for each condition.) Glucose tolerance was tested subsequent to a 16-h fasting period.

*P ≤ 0.05,

†P ≤ 0.01.