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. 2009 Jun 9;58(8):1844–1851. doi: 10.2337/db08-0628

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© 2009 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1 — β-cell destruction by STZ. A: GFP fluorescence of zebrafish pancreatic explants after 3 days in culture (100×). B: Intact zebrafish: lateral views of right side without skin (50×). Top panel: GFP fluorescence in the main pancreas (rostral) and auxiliary islets (green) of vehicle-injected zebrafish. Bottom panel: STZ-injected zebrafish killed after 3 days. C: Vehicle-injected, killed InsGFP zebrafish. Main pancreas was imaged after in situ treatment with propidium iodide (propidium iodide: red fluorescence). D: STZ-injected zebrafish pancreas + propidium iodide after 3 days. (A high-quality digital representation of this figure is available in the online issue.)