TABLE II.
Frequencies of Selected SNPs Among 131 Men With Prostate Cancer and 342 Controls
| SNP/genotype Chromosome | Chromosome | Location of SNP | Nucleotide change |
Prostate cancer cases (n = 131) |
Controls (n = 342) |
Allelic-based age adjusted (1 df) P-value |
Genotype-based age adjusted (2 df) P-value |
Age adjusted OR (95% CI) |
|---|---|---|---|---|---|---|---|---|
| CYP17 | ||||||||
| rs10883783 | 10q24.3 | Intron 7 | A to T | |||||
| AA | 89 (67.94) | 231 (67.74) | — | |||||
| AT | 36 (27.48) | 97 (28.45) | 0.93 (0.58, 1.49) | |||||
| TT | 6 (4.58) | 13 (3.81) | 0.99 | 0.88 | 1.22 (0.44, 3.39) | |||
| rs6163 | 10q24.3 | Exon 1 (Codon 65) | G to T | |||||
| GG | 54 (41.22) | 114 (33.43) | — | |||||
| GT | 52 (39.69) | 192 (56.31) | 0.56 (0.35, 0.88) | |||||
| TT | 25 (19.08) | 35 (10.26) | 0.83 | 0.0014 | 1.59 (0.85, 2.98) | |||
| rs6162 | 10q24.3 | Exon 1 (Codon 46) | C to T | |||||
| CC | 53 (40.46) | 112 (33.23) | — | |||||
| CT | 53 (40.46) | 190 (56.38) | 0.57 (0.36, 0.90) | |||||
| TT | 25 (19.08) | 35 (10.39) | 0.80 | 0.0018 | 1.59 (0.85, 2.97) | |||
| rs743572 | 10q24.3 | 5′-UTR | T to C | |||||
| TT | 52 (41.27) | 106 (32.92) | — | |||||
| CT | 51 (40.48) | 183 (56.83) | 0.55 (0.35, 0.88) | |||||
| CC | 23 (18.25) | 33 (10.25) | 0.97 | 0.0028 | 1.51 (0.79, 2.88) | |||
| CYP3A4 | ||||||||
| rs12333983 | 7q21.1 | 3′-UTR | A to T | |||||
| AA | 55 (44.00) | 141 (43.52) | — | |||||
| AT | 57 (45.60) | 139 (42.90) | 1.11 (0.71, 1.74) | |||||
| TT | 13 (10.40) | 44 (13.58) | 0.75 | 0.62 | 0.79 (0.39, 1.60) | |||
| rs2242480 | 7q21.1 | Intron 10 | A to G | |||||
| AA | 67 (51.15) | 183 (53.51) | — | |||||
| AG | 53 (40.46) | 133 (38.89) | 1.07 (0.69, 1.66) | |||||
| GG | 11 (8.40) | 26 (7.60) | 0.55 | 0.82 | 1.28 (0.59, 2.77) | |||
| rs2740574 | 7q21.1 | 5′-UTR (−293) | G to A | |||||
| GG | 45 (35.16) | 150 (44.25) | — | |||||
| GA | 66 (51.56) | 149 (43.95) | 1.51 (0.96, 2.37) | |||||
| AA | 17 (13.28) | 40 (11.80) | 0.14 | 0.20 | 1.39 (0.71, 2.72) | |||
| CYP19 | ||||||||
| rs700519 | 15q21.1 | Exon 8 (Codon 264) |
C to T | |||||
| CC | 91 (69.47) | 236 (69.21) | — | |||||
| CT | 37 (28.24) | 93 (27.27) | 0.97 (0.61, 1.53) | |||||
| TT | 3 (2.29) | 12 (3.52) | 0.67 | 0.85 | 0.68 (0.18, 2.61) | |||
| SRD5A2 | ||||||||
| rs523349 | 2p23 | Exon 1 (Codon 89) | G to C | |||||
| GG | 71 (54.20) | 177 (51.91) | — | |||||
| GC | 51 (38.93) | 136 (39.88) | 0.86 (0.56, 1.34) | |||||
| CC | 9 (6.87) | 28 (8.21) | 0.36 | 0.65 | 0.72 (0.32, 1.64) | |||
| IGF-1 | ||||||||
| rs5742657 | 12q22-q23 | Intron 2 | A to G | |||||
| AA | 97 (74.62) | 271 (82.12) | — | |||||
| AG | 30 (23.08) | 58 (17.58) | 1.57 (0.94, 2.63) | |||||
| GG | 3 (2.31) | 1 (0.30) | 0.020 | 0.058 | 7.69 (0.77, 77.10) | |||
| rs7965399 | 12q22-q23 | 5′ | T to C | |||||
| TT | 62 (47.69) | 181 (54.85) | — | |||||
| TC | 56 (43.08) | 128 (38.79) | 1.42 (0.91, 2.21) | |||||
| CC | 12 (9.23) | 21 (6.36) | 0.056 | 0.16 | 1.80 (0.82, 3.95) | |||
| IGFBP-3 | ||||||||
| rs3110697 | 7p13-p12 | Intron 3 | G to A | |||||
| GG | 53 (40.46) | 121 (35.59) | — | |||||
| GA | 61 (46.56) | 159 (46.77) | 0.92 (0.58, 1.44) | |||||
| AA | 17 (12.98) | 60 (17.65) | 0.28 | 0.53 | 0.69 (0.36, 1.31) | |||
| rs3793345 | 7p13-p12 | Intron 1 | T to C | |||||
| TT | 89 (67.94) | 201 (58.94) | — | |||||
| TC | 39 (29.77) | 125 (36.66) | 0.75 (0.48, 1.18) | |||||
| CC | 3 (2.29) | 15 (4.40) | 0.11 | 0.25 | 0.44 (0.12, 1.63) |