Table 2.
Treatment Day 8
| Pre-Testing Psychometric and Cocaine Abuse Measures (mean ± SEM | ||
|---|---|---|
| Valproate | Placebo | |
| Beck Depression Inventory (BDI) | 10.6±2.9 | 11.0±2.4 |
| Beck Anxiety Index (BAI) | 4.9±2.1 | 5.2±2.1 |
| Cocaine Abuse: Days use out of last 7 | 3.2±0.5 | 3.7±1.2 |
| Brief Substance Craving Scale (BSCS) | 6.2±0.6 | 5.2±0.6 |
| Cocaine Selective Severity Assessment (CSSA) | 22.2±3.6 | 21.1±3.2 |
| Cocaine Cue Testing - Physiological Measures (mean ± SEM) | ||||
|---|---|---|---|---|
| Valproate | Placebo | |||
| Cocaine Cue | Cocaine Cue | |||
| Pre-Cue | Post-Cue | Pre-Cue | Post-Cue | |
| Heart Rate (beats per minute) | 70.2±3.9 | 76.9±3.2 | 72.1±4.1 | 76.9±2.6 |
| Systolic Blood Pressure (mmHg) | 96.2±6.4 | 98.2±6.8 | 103.0±3.3 | 106.4±3.5 |
| Diastolic Blood Pressure (mmHg) | 61.1±4.1* | 64.4±4.5* | 68.7±2.4 | 69.2±2.2 |
| Plasma Cortisol (μg/dL) | 12.9±1.3* | 11.1±1.1* | 10.1±0.8 | 9.2±0.8 |
| Skin Conductance (μMHO) | 0.911±0.402 | 0.553±0.221 | 0.741±0.296 | 0.496±0.260 |
| Skin Temperature (F°) | 90.5±1.6 | 91.0±1.5 | 89.6±1.5 | 90.7±0.8 |
*
p<0.05 for main effect of medication treatment – valproate vs. placebo