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. 2009 May 10;6(1):37–42. doi: 10.1900/RDS.2009.6.37

Figure 2. Immunocytochemistry of hippocampal dentate gyrus in control, diabetic and diabetic C-peptide-replaced animals.

Figure 2

Increased staining for RAGE (red) and GFAP (green) indicates activation of astrocytes and increased RAGE expression. Merged images confirm the localization of RAGE mainly to astrocytes and their processes. Diabetic rats that received full replacement of rat C-peptide (Table 1) showed prevention of RAGE expression and only minimal GFAP positivity indicative of decreased astrocyte proliferation. Magnification 250X.