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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2009 Jul 7;8(7):1799–1807. doi: 10.1158/1535-7163.MCT-09-0055

Figure 4. Effects of atorvastatin on serum cholesterol, kidney and liver tumors that arise spontaneously in Tsc2+/- mice.

Figure 4

Figure 4

A. Images of H&E stained sections of Tsc2+/- liver hemangioma are shown. Left panel, an untreated 1 year old female mouse; right panel, a 1 year old female mouse treated with atorvastatin for 6 months. Note tortuous irregular vascular channels, some blood-filled, with hyperplastic endothelial cells; magnification is 20×. B. Total and free serum cholesterol was compared in atorvastatin treated mice (At) and controls (Ctrl). Significance is indicated. C. Gross and microscopic kidney tumor scores and percent cellularity of liver hemangioma from control (No Rx) and atorvastatin (Atorva) treated mice are shown. Gender is indicated. The horizontal bar among the data indicates median.