Figure 4.

Reduction of activated microglia, neuronal apoptosis, but not G_M2 storage in bone marrow-transplanted Sandhoff disease mice. Untreated 4-month-old Sandhoff disease mouse [SD (a, c, and e)] and bone marrow-transplanted Sandhoff disease mouse [BMT-SD (b, d, and f)] were analyzed. (a and b) Immunostaining with anti-G_M2 ganglioside antibody. (Bar = 50 μm.) (c and d) TUNEL staining of thalamic nuclei. Arrows indicate apoptotic cells. (Bar = 50 μm.) (e and f) Staining with GSIB4. Arrows indicate GSIB₄-positive cells. (Bar = 20 μm.)