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Effect of GT3 and/or mevalonate administration on overall survival. Panel A: Kaplan-Meier survival curve from mice exposed to 11 Gy TBI. GT3 significantly prolonged survival and reduced lethality (P = 0.001). This effect was not reversed by mevalonate. Panel B: Improvement of the median duration of postirradiation survival by GT3 in mice exposed to 11 Gy TBI (median survival time ± IQR). V: vehicle; M: mevalonate; GT3: γ-tocotrienol; GT3 + M: γ-tocotrienol + mevalonate.
