FIG. 8.
Effect of GT3 and/or mevalonate on postirradiation vascular peroxynitrite formation. GT3 reduced radiation-induced peroxynitrite production in the abdominal aorta at 4 h (P = 0.004) and 3.5 days (P = 0.004) after TBI (abbreviations as in Fig. 1). This effect was reversed by co-treatment with mevalonate, indicating that it is dependent on HMG-CoA reductase inhibition.