TABLE 1.
The Effect of GT3 on Blood Cell Recovery after 8.5 Gy TBI
| Days after TBI | Vehicle | Mevalonate | GT3 | GT3 + mevalonate | |
|---|---|---|---|---|---|
| Erythrocytes (1012/liter) | 0 | 9.7 ± 0.1 | 9.6 ± 0.2 | 9.2 ± 0.3 | 9.3 ± 0.2 |
| 3.5 | 8.9 ± 0.1 | 8.8 ± 0.3 | 9.0 ± 0.3 | 8.8 ± 0.2 | |
| 7 | 7.5 ± 0.2 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.7 ± 0.1 | |
| 14 | 6.0 ± 0.3 | 6.5 ± 0.3 | 9.0 ± 0.1** | 8.9 ± 0.1** | |
| 21 | 9.2 ± 0.4 | 8.4 ± 0.5 | 10.0 ± 0.2 | 10.0 ± 0.2 | |
| Platelets (109/liter) | 0 | 456 ± 23 | 427 ± 10 | 452 ± 12 | 400 ± 12 |
| 3.5 | 390 ± 6 | 384 ± 19 | 437 ± 12 | 475 ± 9 | |
| 7 | 83 ± 4 | 89 ± 3 | 85 ± 5 | 88 ± 6 | |
| 14 | 88 ± 11 | 118 ± 22 | 462 ± 31** | 410 ± 26** | |
| 21 | 264 ± 22 | 224 ± 28 | 371 ± 18** | 365 ± 29* | |
| Leukocytes (109/liter) | 0 | 3.6 ± 0.3 | 4.6 ± 0.5 | 5.1 ± 0.5 | 4.5 ± 0.4 |
| 3.5 | 0.5 ± 0.2 | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.3 ± 0.0 | |
| 7 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.6 ± 0.1 | |
| 14 | 0.5 ± 0.1 | 0.4 ± 0.1 | 2.1 ± 0.4** | 1.6 ± 0.2** | |
| 21 | 1.8 ± 0.1 | 1.2 ± 0.1 | 3.1 ± 0.3** | 2.6 ± 0.1** |
Notes. Values are means ± SEM;
*
P < 0.05;
**
P < 0.005.
At 14 days after irradiation, erythrocyte, platelet and leukocyte counts had recovered significantly in the GT3 group (P = 7 × 10−6; P < 10−6; P < 0.002, respectively) as well as in the GT3 + mevalonate group compared to the vehicle and mevalonate alone groups.