Table 2.
Recirculation of rabbit carotid artery on anastomosis area (*P < 0.05)
| Thrombosis | Partial recirculation | Completely recirculation | |
|---|---|---|---|
| NS control (n = 7) | 4/7 | 3/7 | 0/7 |
| Abciximab 0.2 mg/kg (n = 7) | 2/7 | 3/7 | 2/7 |
| wt-hirudin 1.0 mg/kg (n = 7) | 0/7 | 2/7 | 5/7* |
| r-RGD-hirudin 0.2 mg/kg (n = 7) | 2/7 | 2/7 | 3/7 |
| r-RGD-hirudin 0.5 mg/kg (n = 7) | 0/7 | 3/7 | 4/7* |
| r-RGD-hirudin 1.0 mg/kg (n = 7) | 0/7 | 1/7 | 6/7* |
Compared with NS control, r-RGD-hirudin (0.5, 1.0 mg/kg) and wt-hirudin (1.0 mg/kg) prevented thrombosis at the anastomosis vessels significantly (*P < 0.05). However, in abciximab (0.2 mg/kg) and r-RGD-hirudin (0.2 mg/kg) treatment groups, thrombosis was obvious. The function of the r-RGD-hirudin (0.5 mg/kg) was the same as that of the wt-hirudin (1.0 mg/kg). The antithrombotic effect of r-RGD-hirudin was dose-dependent