Table 3.

Bleeding time

	0.5 h	1.0 h	1.5 h	2.0 h
NS control (n = 7)	107.7 ± 21.1	100.2 ± 13.8	103.0 ± 10.0	104.2 ± 12.0
wt-Hirudin 1.0 mg/kg (n = 7)	146.8 ± 12.5*	131.6 ± 16.6*	120.0 ± 17.9	116.9 ± 15.7
r-RGD-hirudin 0.2 mg/kg (n = 7)	106.7 ± 21.1	118.8 ± 35.3	100.0 ± 26.0	100.5 ± 17.0
r-RGD-hirudin 0.5 mg/kg (n = 7)	134.3 ± 36.2	121.0 ± 25.1	116.7 ± 28.0	102.5 ± 26.8
r-RGD-hirudin 1.0 mg/kg (n = 7)	149.5 ± 25.4*	130.8 ± 24.3*	123.2 ± 20.5	102.5 ± 14.4

Compared with NS control, bleeding time was prolonged after infusion of r-RGD-hirudin for 1.5 h (1.0 mg/kg) and wt-hirudin (1.0 mg/kg) for 1.0 h. *P < 0.05