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. Author manuscript; available in PMC: 2009 Oct 15.
Published in final edited form as: J Immunol. 2008 Oct 15;181(8):5711–5719. doi: 10.4049/jimmunol.181.8.5711

FIGURE 2.

FIGURE 2

Expression and function of CXCR2 in aortic ring model of angiogenesis. A: The relative expression of CXCR2 measured by quantitative RT-PCR is 3.5 fold higher in freshly cut rat aortic rings compared to quiescent rings; ** = P < 0.01; n = 3. B: The angiogenic response of freshly cut rat aortic rings is dose dependently blocked by a CXCR2 inhibitor (SB225002); ** = P < 0.01; *** = P < 0.001; n = 5. C and D: Images of control (C) and SB225002-treated (D) aortic cultures; neovessels are marked by arrows, scale bar = 200 µm. E: Angiogenesis in aortic ring cultures from CXCR2 deficient mice is significantly reduced compared to control cultures. ** = P < 0.01 *** P < 0.001, n = 9.